EZH2 and systemic sclerosis: Indeed, we here and other groups have consistently observed that DZNep not only inhibits EZH2 activity but also decreases its expression in cells including HSCs, SSc dermal fibroblasts, lung fibroblasts, renal fibroblasts, and in fibrotic tissues from diseased animals including liver, lung and kidney 11, 13, 15, 16, 48.