KDM6B and systemic sclerosis: In the setting of SSc, JMJD3, but not UTX, is overexpressed in SSc and murine models of skin fibrosis as well as in cultured fibroblasts, modulates fibroblast activation by regulating H2K27me3 content at FRA2 gene promoter, which encodes the AP1 transcription factor that regulates ECM production.