Another notable aspect of this study is that EZH2 and JMJD3 epigenetically modulate HSCs phenotypes through regulating CDKN1A and GADD45. As a potent cyclin-dependent kinase inhibitor, CDKN1A, also known as p21, regulates cell progression, inhibits proliferation and induces senescence of HSCs, which facilitates the resolution of liver fibrosis 56, 57. Here, EZH2 is linked to Hepatic fibrosis.