Although we did not found clear correlation between JMJD3 expression and fibrosis staging in the cohort of liver fibrosis patients 29, a recent study showed that JMJD3 promotes hepatic autophagy by epigenetically upregulating global autophagy-network genes, the hepatic expression of JMJD3 and these key autophagy genes was substantially decreased in non-alcoholic fatty liver disease (NAFLD) patients (both simple steatosis and advanced NASH-fibrosis patients) as compared to normal subjects 71. The gene discussed is KDM6B; the disease is metabolic dysfunction-associated steatohepatitis.