JMJD2D, or KDM4D, was recently reported as a remarkable overexpressed H3K9me2/3 demethylase during HSCs activation, it epigenetically facilitates TLR4 gene transcription and thus activates TLR4/NF-kB signaling pathways, promotes HSCs activation and hepatic fibrosis progression 21. This evidence concerns the gene TLR4 and Hepatic fibrosis.