EED and Hepatic fibrosis: In the previously reported hepatic transcriptome expression data for 124 liver fibrosis patients (GSE84044 in NCBI GEO) 29, we found that transcriptions of EZH2 (r2 = 0.26, P = 1.25E-09) and other PRC2 components genes, SUZ12, EED and RBBP4 were all positively correlated with sequential histological staging of fibrosis (Scheuer score, S) (Figure 1B), while no significant correlation was observed for JMJD3 (data not shown).