EZH2 is also overexpressed in renal fibrosis 11-13, idiopathic pulmonary fibrosis (IPF) 14, 15, and systemic sclerosis (SSc) 16, a prototypical idiopathic fibrotic disease, its inhibition by DZNep attenuates these fibrotic conditions. This evidence concerns the gene EZH2 and pulmonary fibrosis.