XBP1 and metabolic dysfunction-associated steatotic liver disease: Yao et al. have shown that quercetin ameliorates high-fat diet (HFD)-induced NAFLD by promoting hepatic very low density lipoproteins (VLDL) assembly and lipophagy via the inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α)-X box binding protein 1 (XBP1) pathway 317.