For example, Circ-PVT1 regulates cell growth, metastasis and glycolytic metabolism of oral squamous cell carcinoma via miR-106a-5p/HK2 axis, promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells, enhances cell proliferation but inhibits apoptosis through sponging microRNA-149 in epithelial ovarian cancer, contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis. Here, HK2 is linked to ovarian carcinoma.