CX3CL1 and familial pancreatic carcinoma: In addition, accumulated evidence in pancreatic cancer, colorectal adenocarcinoma, prostate cancer and others, indicate that the CX3CL1-CX3CR1 axis also activates a pro-tumoral response related to several aspects of neoplasia, such as proliferation, migration, invasion, adhesion, apoptosis resistance and the establishment of distant metastases.