Clinical and histopathological evidence on colorectal cancer (CRC) supports an anti-tumoral role of CX3CL1-CX3CR1 axis: in a recent study, the authors examined 80 histologic samples and found a positive correlation between high CX3CL1 immunoreactivity and the number of tumor infiltrating lymphocytes (TILs) including cytotoxic T cells and NK cells; a higher number of TILs is considered an indicator of better clinical prognosis 73. This evidence concerns the gene CX3CL1 and colorectal carcinoma.