ABCB1 and osteosarcoma: Importantly, the knockdown of either CtBP1 or FOXM1 and targeting of the CtBP1-FOXM1 complex members with specific inhibitors, including NSM0018 and NSC95397 for CtBP1, and RCM1 for FOXM1, significantly decreased the MDR1 level and increased the chemosensitivity of osteosarcoma CSCs (Figure 10B).