Tumors (approximately 200 mm3 in size) formed by injection of MG63-R1 and MG63-R2 cells into nude mice responded to combined NSM00158+CDDP or RCM1+CDDP treatments by an 85-90% reduction in tumor volumes compared to untreated or CDDP-treated mice (Figures 9C and 9D). The gene discussed is TNNI3; the disease is neoplasm.