The phenotypes of MG63-R1/R2-CtBP1-KD and MG63-R1/R2-FOXM1-KD cells, as well as the phenotypes of NSM00158-treated MG63-R1/R2 and RCM1-treated MG63-R1/R2 cells, revealed that knockdown or blockage of CtBP1 and FOXM1 caused similar effects on cell proliferation, colony formation, sphere formation, cell migration, and suppression of tumor growth. Here, TNNI3 is linked to neoplasm.