NDRG4 and colorectal cancer: The DNA methylation biomarkers BMP3 (bone morphogenetic protein 3), NDRG4 (N-myc downstream-regulated gene 4) and SDC2 (syndecan-2) has been extensively studied and are served as an alternative method in screening colorectal cancers and neoplasms 5, 16, 31, 35-44.