Studies reported that the stool test of methylated SDC2 detected 81.1% of colorectal cancer and 58.2% of adenomas at a specificity of 93.3% based on the Chinese population 16, while for the South Korean population, results showed that SDC2 methylation in stool detected 90.2%, 66.7%, and 24.4% of colorectal cancer, advanced and non-advanced adenomas, respectively 45. The gene discussed is SDC2; the disease is colorectal cancer.