41 The knockdown of TRIM37 expression by transfection with siRNA-TRIM37 suppressed the production of ZEB1 and induced the production of E-cadherin in both TP53 wild-type and TP53 mutant cells (NUGC4 and MKN7, Figure 3A). These results suggest that overexpression of TRIM37 induces cell migration and invasion via the loss of E-cadherin. Figure 3B shows a hypothetical model of the overexpression of TRIM37 in GC cells. This evidence concerns the gene TP53 and gastric cancer.