The promoter sequence of hnRNP-F identified by a PubMed database search was used to evaluate transcription factor binding and activity on hnRNP-F via ALGGEN, and the downstream molecule FOXO1, which is regulated by PI3K/AKT, was selected to examine the association of hnRNP-F with the PI3K/AKT signalling pathway in BC (Figure 4A). The gene discussed is AKT1; the disease is breast cancer.