MiR-133a could act as a tumor-suppressor by targeting and downregulating eukaryotic translation initiation factor 4A1 (eIF4A1) 52, matrix metallopeptidase 9 (MMP9) 53, 54, MMP14 55, membrane-type 1 matrix metalloproteinase (MT1-MMP) 56, Fascin1 (FSCN1) 57-59, phosphodiesterase 7A (PDE7A) 60, Coronin-1C (CORO1C) 61 and Sox4 62. The gene discussed is MMP9; the disease is neoplasm.