In nasopharyngeal carcinoma (NPC), cinobufotalin (CB) induced FOXO1-mediated cisplatin sensitivity by down-regulating MYH9 which was colocalized with FOXO1 in the cytoplasm via the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway 105. The gene discussed is MYC; the disease is nasopharyngeal carcinoma.