The results of univariate analysis indicated that pleural invasion, differentiation grade, tumor length, T stage, N stage, TNM stage, and LIMCH1 expression were associated with overall survival in patients with LUAD, and multivariate analysis confirmed that LIMCH1 expression (HR 0.545, 95% CI 0.358-0.830), N stage (HR 3.618, 95% CI 1.281-10.217), and TNM stage (HR 3.662, 95% CI 2.261-5.931) were independent prognostic factors (Table 4). This evidence concerns the gene LIMCH1 and neoplasm.