In general, ALK activates multiple signaling pathways, such as the PI3K-AKT, CRKL-C3G, MEKK2/3-MEK5-ERK5, JAK-STAT and MAPK signaling pathways 19, which involved in the initiation and progression of many different cancer types, including lymphomas, neuroblastoma and colorectal cancer. This evidence concerns the gene RAPGEF1 and cancer.