As a member of the cadherin superfamily, CDH11 is responsible for the formation of the cadherin junctions in most cell types, and the loss of cell-cell adhesion often leads to enhanced migration, invasion and metastasis 28, 29, which could in part explain why the downregulation of CDH11 promoted invasion, migration and PTX resistance in GC patients with PM. This evidence concerns the gene CDH11 and gastric cancer.