TGFB1 and neoplasm: TAMs can restrain the normal course of antigen presentation, such as by secreting cytokines and inflammatory mediators like IL-10, transforming growth factor beta (TGF-β), prostaglandin E2 (PGE2) and matrix metalloproteinase 7 (MMP-7), thereby making T cells lose the ability to distinguish or even kill tumor cells, which create an immunosuppressive microenvironment 9.