For example, because of the proliferation but no differentiation of the CD4+ naïve T cells, the CD4+ regulatory T cells (C08_CD4-CTLA4), which are thought to be derived from the same lineage as the CD4+ naïve T cells 54, showed the similar proportion in HCV-HCC and normal liver tissue. The gene discussed is CTLA4; the disease is hepatocellular carcinoma.