MELK and neoplasm: In this study, 12 pathological hub genes (AURKA, BUB1B, CCNB2, CDK1, CDT1, HJURP, KIF20A, KIF2C, KIF4A, MELK, TPX2, and UBE2C) that are significantly related to the pathological stage were identified and verified, and significant differences can also be found in the expression value of each hub gene between different tumor stages and grades.