Mutations were discovered in 59% (44 of 74) of probands in Saint-Petersburg with verified FH in whom all exons of LDLR were completely investigated, including alterations that (in our opinion) likely caused the disease in 55% of families with FH (41 of 74); however, the most interesting result was not finding novel and/or known mutations in families considered separately, which was expected in the poorly explored Russian population, but detection of mutations that were ethnically specific. The gene discussed is LDLR; the disease is familial hyperaldosteronism.