IGHE and anaphylaxis: Furthermore, pretreatment with the humanized non-fucosylated IgG1 anti-Siglec-8 antibody lirentelimab (Allakos, Inc.)completely prevented human IgE-mediated PSA in NSG-SGM3 BLT humanized mice (61), suggesting that it may be a useful therapy for preventing anaphylaxis in humans.