NLRP3 and staphylococcus aureus infection: Staphylococcus aureus infection of wounds upregulates keratinocyte IL-1 that drives neutrophil recruitment via IL-1R1 signaling (180), while NLRP3 activation is also seen after sterile burn injuries, with Nlrp3-/- mice showing reduced macrophage infiltration and impaired healing after chemical burns (181).