Reduced expression of IFNα (p<0.001), IFNβ (p<0.0001), IRF-7 (p<0.0001), and FOXO3 (p<0.001) transcripts were observed in patients with severe dengue (DHF/DSS patients) than patients with non-severe manifestations (DF patients) (Figures 5A–C). This evidence concerns the gene FOXO3 and dengue disease.