A systems-wide analysis of the adjuvant Poly(I:C) has been shown to augment induction of diverse innate signaling pathways such as Toll-like receptor-7 (TLR-7), TLR-4, retinoic acid inducible gene-I (RIG-I), melanoma differentiation-associated protein-5 (MDA-5), protein kinase RNA-activated (PKR), type I interferons (IFNs), complement, and inflammasomes identical to that of a live attenuated yellow fever vaccine in humans (9), confirming the potency and authenticity of Poly(I:C) as an efficacious adjuvant. Here, RIGI is linked to viral infectious disease.