PDCD1 and non-small cell lung carcinoma: When PD-1/PD-L1 inhibitors were compared with chemotherapy, the risk of paraesthesia of all grades was obviously lower [OR = 0.23, 95%CI:(0.14, 0.36), I2 = 0%, Z = 6.40 (P < 0.00001); Figure 6A] (25, 28, 32, 41, 43, 44, 49), especially for subgroups relating to NSCLC and UC (32, 41, 43, 44).