MOG and neuromyelitis optica: Differential diagnoses for MS are neuromyelitis optica (NMO) and major oligodendrocyte glycoprotein (MOG) Ab-associated demyelinating disease, but other diseases may also mimic some aspects of MS, including acute disseminated encephalomyelopathy (ADEM), CNS neoplasms and various other diseases with the potential to affect the CNS (20–22).