TNF and Hepatic fibrosis: Consistently, aggravated liver fibrosis development in TcrbKO mice was confirmed by elevated fibrogenic gene expression (Sma, Col1, Tgfb), along with abnormal intrahepatic immune status (including alleviated levels of Il2, Il6, Il23, Ifng, and enhanced levels of Il17 and Tnfa) (Figures 5B, C).