In experiments with NPs that contained only IL-2, NK cells markedly influenced the serum levels of autoantibodies in BDF1 lupus mice that received NPs, as depletion of NK cells with anti-asialo GM1 resulted in significantly increased titers of anti-dsDNA autoantibodies (Figure 3) and accelerated renal disease manifestations (proteinuria) (Figure 4A). The gene discussed is IL2; the disease is kidney disorder.