ANGPT2 and acute lymphoblastic leukemia: In contrast, in pediatric patients with ALL who received CD19-directed CAR T cells, there was no association of ICANS with serum markers of coagulopathy and/or endothelial activation, including VEGF-A, VWF, Ang-1, Ang-2, Ang-2/1 ratio, peak INR and D-Dimer, or nadir fibrinogen levels and platelet counts (8).