Given the contribution of immunity and inflammation to the pathology of NASH, and the potential for MR to modulate immune responses, MR antagonism or MR knock-down have been evaluated to prevent steatosis and fibrosis in NASH dietary animal models using either high fat (27) or choline-deficient-amino-acid-defined (CDAA) diets (28). This evidence concerns the gene NR3C2 and metabolic dysfunction-associated steatohepatitis.