IFNB1 and infection: These results demonstrated that BFRF1 could effectively prevent the phosphorylation and dimerization of IRF3 during EBV lytic infection, which was also consistent with the results of Figures 2A, B, again confirming EBV lytic infection could inhibit the production of IFN-β and downstream ISG, and BFRF1 played a certain important role in this process.