To address the primary objective of this study, which is the identification of genes involved in the resistance to innate immune defenses, in the second step of the screen, we evaluated the virulence of the four PSC insertion mutants upon a septic injury infection in adult Drosophila. This infection model, previously established on the wt and the dlt mutant strains of Bt407, allows the discrimination between virulent and attenuated strains (Kamar et al., 2017; Figure 1). The gene discussed is CDAN1; the disease is infection.