PRKG1 and malaria: Importantly, 1 was also shown to have inhibitory activity against malaria parasites (Diaz et al., 2006) and has (along with 2) subsequently been used, in conjunction with transgenic lines expressing inhibitor resistant PKG alleles, to unequivocally determine the function of PKG throughout the malaria parasite life cycle (Baker et al., 2017a) (Figure 2).