To further exclude the potential confounder of hyperglycemia, HbA1c was adjusted by univariate general linear model, and the expression of SELL, ITGA4, ITGAM, NCF4, ARHGAP3, and CLDN15 remained significantly higher in neutrophils from LADA, but not T2DM, compared with healthy controls; and the expression of SELL, ITGA4, ARHGAP3, and CLDN15 remained significantly higher in neutrophils from LADA compared with those from T2DM. Here, NCF4 is linked to Hyperglycemia.