It is worth noting that in this study, 8 (ACTR3, ARF4, PGRMC1, RPS23, WDR12, ACTR2, SIAH1, and RPS27L) of 12 hub genes are related to cancers, such as lung cancer, epithelial ovarian cancer, gastric cancer, glioblastoma, breast cancer, and esophageal cancer (51, 54, 57–63). This evidence concerns the gene ACTR2 and esophageal cancer.