ACTR3 and esophageal cancer: It is worth noting that in this study, 8 (ACTR3, ARF4, PGRMC1, RPS23, WDR12, ACTR2, SIAH1, and RPS27L) of 12 hub genes are related to cancers, such as lung cancer, epithelial ovarian cancer, gastric cancer, glioblastoma, breast cancer, and esophageal cancer (51, 54, 57–63).