Angiotensin II type 1 receptor (AT1) plays an important role in the HFD-induced phenotypic alteration of aortic PVAT in ApoE–/– mice, identified as higher expression of proinflammatory cytokines and inflammatory cell infiltration, and modulation of AT1 may exert beneficial effects on atherosclerosis (Irie et al., 2015). Here, AGTR1 is linked to atherosclerosis.