APOE and atherosclerosis: Angiotensin II type 1 receptor (AT1) plays an important role in the HFD-induced phenotypic alteration of aortic PVAT in ApoE–/– mice, identified as higher expression of proinflammatory cytokines and inflammatory cell infiltration, and modulation of AT1 may exert beneficial effects on atherosclerosis (Irie et al., 2015).