The upregulated expression of Nedd4-2, co-localization of Nedd4-2 with NaV1.5, and increased diastolic calcium concentrations were observed in the volume-overloaded HF rat model, suggesting that Nedd4-2-mediated ubiquitination plays an important role in the downregulation of NaV1.5 in HF (Luo et al., 2017). Here, NEDD4L is linked to hydrops fetalis.