On the other hand, CaMKII abnormities were considered to promote ectopic activities such as early afterdepolarizations (EAD) (Qi et al., 2009) and delayed afterdepolarizations (DAD) (Dobrev et al., 2011), and to improve reentry generations by increasing the repolarization dispersion (Yue et al., 2011) or slowing the conduction velocity of the electrical wave (Wagner et al., 2006; Wang et al., 2018), all of which were the key mechanisms related to AF. The gene discussed is CAMK2G; the disease is atrial fibrillation.