For example, TRPV1-positive afferents in the pancreas has been implicated in the pathomechanism of diabetes; in the gastrointestinal system they were linked to thermoregulation; in the respiratory system their activation causes cough; and in the urinary bladder they alre involved in the micturition reflex (Moran et al., 2011). The gene discussed is TRPV1; the disease is diabetes mellitus.