With ATDs use, hyperthyroidism of Init_GD patients gradually eased, fT3 and fT4 levels decreased even the TSH level remained low, and Tg-Ab and TPO-Ab levels showed decreasing trends, while the TPO-Ab level showed no significant difference between the Init_GD and Treat_GD groups (p = 0.319, Supplementary Table S1). Here, TPO is linked to hyperthyroidism.