FOXO3 and lung cancer: For example, DDP inhibits the phosphorylation of FoxO3α and induces the accumulation of FoxO3α in the nucleus by inhibiting the PI3K/Akt pathway, thus increasing the expression of the FoxO3α-dependent apoptotic protein BIM, inhibiting the proliferation of lung cancer cells and inducing apoptosis (Liu et al., 2014).