ESR1 (estrogen receptor α), PTGS2 (cyclooxygenase-2), ALOX12 (12-lipoxygenase), AChE, GABRG1 (gamma-aminobutyric acid A receptor), TNF (tumor necrosis factor alpha), BACE1 (β-secreatase), APP (β-amyloid precursor protein), CDK5 (cyclin-dependent kinase 5), MAPT (microtubule-associated protein tau), GSK3β (glycogen synthase kinase 3 beta) and MAOB (monoamine oxidase B) were hub targets of the network, which suggested that they were main targets for XXMD formula to treat with AD. Here, ALOX12 is linked to Alzheimer disease.