NLRP3 and Hepatic fibrosis: In mice with CCl4-induced liver fibrosis, oridonin treatment significantly reduces the collagen deposition, HSCs (cells associated with hepatic fibrosis) activation, and recruitment of Kupffer cells, which may be related to its inhibitory effect on NLRP3 inflammasome activation in HSCs, highlighting the potential of the compound for use in the treatment of liver fibrosis.