NLRP3 and renal fibrosis: Dihydroquercetin, a dihydroflavone compound, has been reported to attenuate the expression of renal fibrosis-associated proteins fibronectin and collagen IV in high glucose stimulated rat kidney mesangial cells (HBZY-1) and HK-2 cells, which may be associated with the suppression of mitochondrial ROS generation as well as NLRP3 inflammasome activation (Ding et al., 2018).