In thioacetamide (TAA)-stimulated liver fibrosis of mice, 25-OCH3-PPD possesses the ability to reduce the expression levels of TIMP-1, MMP-13, and collagen I as well as the inhibition of ECM deposition, which is partially due to the regulation of NLRP3 inflammasome signaling pathway by affecting P2X7R activation (Han et al., 2018; Su et al., 2019). Here, NLRP3 is linked to Hepatic fibrosis.