In models of potassium oxonate (PO)-induced hyperuricemia and high adenine diet (HAD)-induced chronic kidney disease (CKD), pterostilbene-triggered autophagy has an attenuating effect on the improvement of renal function and interstitial fibrosis via restraining EMT-mediated NLRP3 inflammasome activation (Wang et al., 2020d). The gene discussed is NLRP3; the disease is chronic kidney disease.