ACE2 and severe acute respiratory syndrome: The disruption of the physiological balance between ACE/ACE2 and the angiotensin II/angiotensin system by SARS-CoV infection plays a pathogenic role in SARS-CoV–induced lung injury (Kuba et al., 2006; Yamamoto et al., 2006; Imai et al., 2008; Wu, 2020).