A significant reduction in the IκBα expression and increase in the expression of p-p65 and p-IκBα were observed in MDD rats compared with the CTL rats, whereas pinocembrin significantly increased the IκBα expression and reduced the expression levels of p-p65 and p-IκBα in MDP rats (Figures 9D–G). The gene discussed is NFKBIA; the disease is major depressive disorder.