Infusion of CER-001 did not promote regression of coronary atherosclerosis in statin-treated patients with ACS and high plaque burden (Nicholls et al., 2018), which may be due to the strong (50%) downregulation of ABCA1 mRNA and membrane protein expression at higher doses of CER-001 (Tardy et al., 2015). The gene discussed is ABCA1; the disease is coronary atherosclerosis.