It is worth remarking, however, that biallelic variants in CACNA2D2 are detected in an early onset form of epileptic encephalopathy, which shares some clinical features with CLN1 disease (Brill et al., 2004; Ivanov et al., 2004; Punetha et al., 2019). This evidence concerns the gene CACNA2D2 and Epileptic encephalopathy.