FMRP has been identified to directly target mRNA transcripts of multiple GABAA subunits and GABA transporter Slc6a1 (Miyashiro et al., 2003; Darnell et al., 2011; Ascano et al., 2012; Braat and Kooy, 2015; Braat et al., 2015), including lowered GABAA receptor subunit mRNA and protein levels in both FXS mouse and Drosophila models (El Idrissi et al., 2005; D’Hulst et al., 2006; Gantois et al., 2006; Adusei et al., 2010). The gene discussed is FMR1; the disease is fragile X syndrome.