FXS researchers have used preclinical FXS models, like the Fmr1 KO mouse (The Dutch-Belgian Fragile X Consortium, 1994; Dahlhaus, 2018) to develop novel therapeutic strategies that have found shown promise for clinical translation, however, many clinical trials employing these strategies, unfortunately, do not pass Phase 3 (Gross et al., 2015; Ligsay and Hagerman, 2016). This evidence concerns the gene FMR1 and fragile X syndrome.