Some important examples include the use of corticotrophin releasing factor receptor one antagonists for anxiety (Kaffman et al., 2019), mGluR5 antagonists to rescue cognitive and social deficits in fragile X syndrome knockout mice (Bhakar et al., 2012; Berry-Kravis et al., 2016), and the use of N-acetylcysteine for drug addiction (Nocito Echevarria et al., 2017; Spencer and Kalivas, 2017). Here, GRM5 is linked to Anxiety.