It is worth mentioning that although the g.15691175_15691176GC > CT mutation associated with lissencephaly-4 also occurs in the absence of one NDE1 allele, the degree of truncation is not as severe as g.15667332 C > T and does not have any non-native residues such as g.15696821_15696822delGA. Here, NDE1 is linked to lissencephaly 4.