Studies have shown that oligodendrocyte differentiation is impaired in schizophrenia (Davis and Haroutunian, 2003; Hattori et al., 2014; Mauney et al., 2015) and that DISC1 negatively regulates the differentiation of oligodendrocyte precursors (Porteous and Millar, 2009). The gene discussed is DISC1; the disease is schizophrenia.