In the present study, we demonstrated that i.p. administrated BBB-permeable ENT-1 inhibitors, JMF1907 and J4, can produce beneficial effects in various seizure models, including seizure induced by MES, high dose PTZ, and low dose PTZ kindling that represent generalized tonic-clonic seizure, generalized myoclonic seizure, and focal seizure, respectively. Here, SLC29A1 is linked to Seizure.