TLR4 and Alzheimer disease: Several other SNPs of TLR4 have been reported to confer neuroprotection in the Han Chinese population—i.e., rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs7037117, and rs7045953, whereas rs11367 and rs1927907 increase the risk of AD (Wang et al., 2011; Chen et al., 2012; Yu et al., 2012).