Hou and colleagues described that hypoxia-inducible factor-2α (HIF-2α) inhibits YTHDF2 expression, resulting in elevated expression of m6A-containing interleukin 11 (IL11) and serpin family E member 2 (SERPINE2) mRNAs, which further leads to inflammation and vascular abnormalities in HCC 151. The gene discussed is SERPINE2; the disease is hepatocellular carcinoma.