Liu et al. reported that SIRT1 activate RANBP2 that mediates FTO SUMOylation and degradation, and subsequently leads to m6A deposition in HCC tumor suppressor guanine nucleotide-binding protein G (o) subunit alpha (GNAO1) and inhibits its mRNA expression, and consequently results in liver cancer progression 139. The gene discussed is FTO; the disease is liver cancer.