Zhong et al. demonstrated that hypoxia down-regulated YTHDF2 expression, and forced YTHDF2 expression could suppress HCC carcinogenesis, proliferation and activation of MEK and ERK in HCC cells through directly binding the m6A sites on EGFR 3'UTR and subsequently promoting its degradation 129. The gene discussed is EGFR; the disease is hepatocellular carcinoma.