HES1 and hepatocellular carcinoma: Based on well-recognized BCSC markers (CD44highCD24low) 21, BCSC populations (the ratio of CD44highCD24low cell fractions) were clearly decreased upon HES1 knockdown in forming tumorspheres of TNBC cell lines (MDA-MB-231 and HCC-1937), whereas also restored by Slug overexpression.